輔酶Q–細胞色素c還原酶

跳轉到：導航, 搜索

A+醫學百科 >> 輔酶Q–細胞色素c還原酶

泛醇—細胞色素c還原酶（英語：Ubiquinol-cytochrome-c reductase，EC 1.10.2.2）在酶學中是指一種催化如下化學反應的酶：

QH₂ + 2 高鐵細胞色素c $\rightleftharpoons$ Q + 2 亞鐵細胞色素c + 2 H⁺

因此，此酶的兩個底物分別是二氫醌（QH₂）與高鐵（Fe³⁺）細胞色素c，而其三個產物則分別是醌（Q）、亞鐵（Fe²⁺）細胞色素c以及氫離子。

參考文獻

↑ PDB 1ntz; Gao X, Wen X, Esser L, Quinn B, Yu L, Yu CA, Xia D. Structural basis for the quinone reduction in the bc1 complex: a comparative analysis of crystal structures of mitochondrial cytochrome bc1 with bound substrate and inhibitors at the Qi site. Biochemistry. August 2003, 42 (30): 9067–80. doi:10.1021/bi0341814. PMID 12885240.

Marres CM, Slater EC. Polypeptide composition of purified QH2:cytochrome c oxidoreductase from beef-heart mitochondria. Biochim. Biophys. Acta.. 1977, 462 (3): 531–548. doi:10.1016/0005-2728(77)90099-8. PMID 597492.
Rieske JS. Composition, structure, and function of complex III of the respiratory chain. Biochim. Biophys. Acta.. 1976, 456 (2): 195–247. PMID 788795.
Wikstrom M, Krab K, Saraste M. Proton-translocating cytochrome complexes. Annu. Rev. Biochem.. 1981, 50: 623–655. doi:10.1146/annurev.bi.50.070181.003203. PMID 6267990.