無機(jī)焦磷酸酶（英語：Inorganic Pyrophosphatase，簡稱為焦磷酸酶）是一種催化一分子焦磷酸鹽轉(zhuǎn)化為兩分子磷酸鹽離子的酶[1]。這是一個高放能的反應(yīng)，因此此反應(yīng)可偶聯(lián)到一些熱力學(xué)上不利的轉(zhuǎn)化，以便驅(qū)動這些轉(zhuǎn)化進(jìn)行到完全[2]。此酶的功能乃是在脂代謝（包括脂合成與講解）、鈣吸收以及骨形成[3][4]和DNA合成[5]中扮演重要角色，其他生物化學(xué)轉(zhuǎn)化也是如此[6][7]。
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參考文獻(xiàn)
- ↑ Harold FM. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC441015/ Inorganic polyphosphates in biology: structure, metabolism, and function]. Bacteriol Rev. December 1966, 30 (4): 772–94. PMID 5342521. PMC 441015.
- ↑ Terkeltaub RA. Inorganic pyrophosphate generation and disposition in pathophysiology. Am. J. Physiol., Cell Physiol.. July 2001, 281 (1): C1–C11. PMID 11401820.
- ↑ Orimo H, Ohata M, Fujita T. Role of inorganic pyrophosphatase in the mechanism of action of parathyroid hormone and calcitonin. Endocrinology. September 1971, 89 (3): 852–8. doi:10.1210/endo-89-3-852. PMID 4327778.
- ↑ Poole KE, Reeve J. Parathyroid hormone - a bone anabolic and catabolic agent. Curr Opin Pharmacol. December 2005, 5 (6): 612–7. doi:10.1016/j.coph.2005.07.004. PMID 16181808.
- ↑ Nelson, David L.; Cox, Michael M.. Lehninger Principles of Biochemistry, 3rd ed.. New York: Worth Publishers. 2000: pp. 937. ISBN 1-57259-153-6.
- ↑ Ko KM, Lee W, Yu JR, Ahnn J. PYP-1, inorganic pyrophosphatase, is required for larval development and intestinal function in C. elegans. FEBS Lett.. November 2007, 581 (28): 5445–53. doi:10.1016/j.febslet.2007.10.047. PMID 17981157.
- ↑ Usui Y, Uematsu T, Uchihashi T, et al.. Inorganic polyphosphate induces osteoblastic differentiation. J. Dent. Res.. May 2010, 89 (5): 504–9. doi:10.1177/0022034510363096. PMID 20332330.
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