線(xiàn)粒體三功能酶β亞基（英語(yǔ)：Trifunctional enzyme subunit beta, mitochondrial，TP-beta）也被稱(chēng)為3-ketoacyl-CoA thiolase、acetyl-CoA acyltransferase或beta-ketothiolase 是一種由人類(lèi)基因 HADHB 所編碼的酶[1]。
HADHB是線(xiàn)粒體三功能蛋白的一個(gè)亞基，并具有硫解酶活性。
功能
參考文獻(xiàn)
延伸閱讀
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- Adams DJ, Beveridge DJ, van der Weyden L, et al.. HADHB, HuR, and CP1 bind to the distal 3'-untranslated region of human renin mRNA and differentially modulate renin expression.. J. Biol. Chem.. 2003, 278 (45): 44894–903. doi:10.1074/jbc.M307782200. PMID 12933794.
- Spiekerkoetter U, Khuchua Z, Yue Z, et al.. General mitochondrial trifunctional protein (TFP) deficiency as a result of either alpha- or beta-subunit mutations exhibits similar phenotypes because mutations in either subunit alter TFP complex expression and subunit turnover.. Pediatr. Res.. 2004, 55 (2): 190–6. doi:10.1203/01.PDR.0000103931.80055.06. PMID 14630990.
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- Purevsuren J, Fukao T, Hasegawa Y, et al.. Clinical and molecular aspects of Japanese patients with mitochondrial trifunctional protein deficiency.. Mol. Genet. Metab.. 2009, 98 (4): 372–7. doi:10.1016/j.ymgme.2009.07.011. PMID 19699128.
- Hillier LW, Graves TA, Fulton RS, et al.. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.. Nature. 2005, 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
- Spiekerkoetter U, Sun B, Khuchua Z, et al.. Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit mutations.. Hum. Mutat.. 2003, 21 (6): 598–607. doi:10.1002/humu.10211. PMID 12754706.
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- Fould B, Garlatti V, Neumann E, et al.. Structural and functional characterization of the recombinant human mitochondrial trifunctional protein.. Biochemistry. 2010, 49 (39): 8608–17. doi:10.1021/bi100742w. PMID 20825197.
- Strausberg RL, Feingold EA, Grouse LH, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/ Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.]. Proc. Natl. Acad. Sci. U.S.A.. 2002, 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. PMC 139241.
- Ibdah JA, Tein I, Dionisi-Vici C, et al.. Mild trifunctional protein deficiency is associated with progressive neuropathy and myopathy and suggests a novel genotype-phenotype correlation.. J. Clin. Invest.. 1998, 102 (6): 1193–9. doi:10.1172/JCI2091. PMID 9739053.
- Gevaert K, Goethals M, Martens L, et al.. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.. Nat. Biotechnol.. 2003, 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
- Hendrickson SL, Lautenberger JA, Chinn LW, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2943476/ Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.]. PLoS ONE. 2010, 5 (9): e12862. doi:10.1371/journal.pone.0012862. PMID 20877624. PMC 2943476.
- Frackowiak J, Mazur-Kolecka B, Kaczmarski W, Dickson D. Deposition of Alzheimer's vascular amyloid-beta is associated with decreased expression of brain L-3-hydroxyacyl-coenzyme A dehydrogenase (ERAB).. Brain Res.. 2001, 907 (1-2): 44–53. doi:10.1016/S0006-8993(01)02497-0. PMID 11430884.
外部鏈接
HADHB引用了美國(guó)國(guó)家醫(yī)學(xué)圖書(shū)館提供的資料，這些資料屬于公共領(lǐng)域。
參考來(lái)源
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