組氨酸解氨酶（英語：Histidine ammonia-lyase，或稱為組氨酸氨裂解酶或組氨酸酶）在人體中是一種由HAL基因編碼的酶[1][2]。組氨酸解氨酶將組氨酸轉(zhuǎn)變?yōu)榘迸c尿刊酸。
功能
組氨酸解氨酶是一種胞質(zhì)溶膠酶，催化組氨酸代謝過程中的第一步，即L-組氨酸的非氧化脫氨形成反式尿刊酸[1]。
編碼組氨酸酶的基因的突變與組氨酸血癥和尿刊酸尿癥兩者有關(guān)。
深入閱讀
- Suchi M, Harada N, Wada Y, Takagi Y. Molecular cloning of a cDNA encoding human histidase.. Biochim. Biophys. Acta. 1993, 1216 (2): 293–5. PMID 7916645.
- Davila S, Froeling FE, Tan A, et al.. New genetic associations detected in a host response study to hepatitis B vaccine.. Genes Immun.. 2010, 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
- Gerhard DS, Wagner L, Feingold EA, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC528928/ The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).]. Genome Res.. 2004, 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. PMC 528928.
- Eckhart L, Schmidt M, Mildner M, et al.. Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid.. J. Dermatol. Sci.. 2008, 50 (3): 209–15. doi:10.1016/j.jdermsci.2007.12.009. PMID 18280705.
- Welsh MM, Karagas MR, Applebaum KM, et al.. A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions.. Carcinogenesis. 2008, 29 (10): 1950–4. doi:10.1093/carcin/bgn160. PMID 18641401.
- Strausberg RL, Feingold EA, Grouse LH, et al.. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC139241/ Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.]. Proc. Natl. Acad. Sci. U.S.A.. 2002, 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. PMC 139241.
- Kawai Y, Moriyama A, Asai K, et al.. Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene.. Hum. Genet.. 2005, 116 (5): 340–6. doi:10.1007/s00439-004-1232-5. PMID 15806399.
- Taylor RG, Garcí-a-Heras J, Sadler SJ, et al.. Localization of histidase to human chromosome region 12q22----q24.1 and mouse chromosome region 10C2----D1.. Cytogenet. Cell Genet.. 1991, 56 (3-4): 178–81. PMID 2055114.
- Alemán G, Ortí-z V, Langley E, et al.. Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells.. Am. J. Physiol. Endocrinol. Metab.. 2005, 289 (1): E172-9. doi:10.1152/ajpendo.00584.2004. PMID 15741241.
參考文獻(xiàn)
外部鏈接
組氨酸解氨酶引用了美國國家醫(yī)學(xué)圖書館提供的資料，這些資料屬于公共領(lǐng)域。
參考來源
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