表皮生長因子受體
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表皮生長因子受體（英語：epidermal growth factor receptor，簡稱為EGFR、ErbB-1或HER1）是一類名為表皮生長因子家族（EGF-家族）的細胞外蛋白配體的細胞表面受體[2] 。
表皮生長因子受體是ErbB受體家族家族的成員之一，ErbB家族是包含四種緊密聯(lián)系蛋白的亞家族，這四種蛋白分別是受體酪氨酸激酶類：EGFR（ErbB-1）HER2/c-neu（ErbB-2）、Her 3（ErbB-3）以及Her 4（ErbB-4）。影響EGFR表達或活性的突變可能導致癌癥[3]。
表皮生長因子及其受體是由范德堡大學的斯坦利·科恩發(fā)現(xiàn)的，科恩與麗塔·列維-蒙塔爾奇尼因發(fā)現(xiàn)生長因子類而共同獲得了1986年諾貝爾生理學或醫(yī)學獎。
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表皮生長因子受體（EGFR）存在于細胞表面且因結合特異性受體而被激活，這些受體包括表皮生長因子和TGFα。ErbB2并無已知的直接激活配體，可能結構性地處于激活狀態(tài)，或在與如EGFR等其他家族成員形成異源二聚體時被激活。
參考文獻
- ↑ PMID 12620237（PubMed）
本引用來源將會在數(shù)十分鐘后自動完成。您可以檢查英文對應模板或手動擴充 - ↑ Herbst RS. Review of epidermal growth factor receptor biology. Int. J. Radiat. Oncol. Biol. Phys.. 2004, 59 (2 Suppl): 21–6. doi:10.1016/j.ijrobp.2003.11.041. PMID 15142631.
- ↑ Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC1934579/ ErbB receptors: from oncogenes to targeted cancer therapies]. J. Clin. Invest.. August 2007, 117 (8): 2051–8. doi:10.1172/JCI32278. PMID 17671639. PMC 1934579.
深入閱讀
- Carpenter G. Receptors for epidermal growth factor and other polypeptide mitogens. Annu. Rev. Biochem.. 1987, 56 (1): 881–914. doi:10.1146/annurev.bi.56.070187.004313. PMID 3039909.
- Boonstra J, Rijken P, Humbel B, et al.. The epidermal growth factor. Cell Biol. Int.. 1995, 19 (5): 413–30. doi:10.1006/cbir.1995.1086. PMID 7640657.
- Carpenter G. The EGF receptor: a nexus for trafficking and signaling. BioEssays. 2000, 22 (8): 697–707. doi:10.1002/1521-1878(200008)22:8<697::AID-BIES3>3.0.CO;2-1. PMID 10918300.
- Filardo EJ. Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer. J. Steroid Biochem. Mol. Biol.. 2002, 80 (2): 231–8. doi:10.1016/S0960-0760(01)00190-X. PMID 11897506.
- Tiganis T. Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor. IUBMB Life. 2002, 53 (1): 3–14. doi:10.1080/15216540210811. PMID 12018405.
- Di Fiore PP, Scita G. Eps8 in the midst of GTPases. Int. J. Biochem. Cell Biol.. 2002, 34 (10): 1178–83. doi:10.1016/S1357-2725(02)00064-X. PMID 12127568.
- Benaim G, Villalobo A. Phosphorylation of calmodulin. Functional implications. Eur. J. Biochem.. 2002, 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
- Leu TH, Maa MC. Functional implication of the interaction between EGF receptor and c-Src. Front. Biosci.. 2004, 8 (1-3): s28–38. doi:10.2741/980. PMID 12456372.
- Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol. Cell Proteomics. 2003, 1 (11): 845–67. doi:10.1074/mcp.R200007-MCP200. PMID 12488461.
- Kari C, Chan TO, Rocha de Quadros M, Rodeck U. Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage. Cancer Res.. 2003, 63 (1): 1–5. PMID 12517767.
- Bonaccorsi L, Muratori M, Carloni V, et al.. Androgen receptor and prostate cancer invasion. Int. J. Androl.. 2003, 26 (1): 21–5. doi:10.1046/j.1365-2605.2003.00375.x. PMID 12534934.
- Reiter JL, Maihle NJ. Characterization and expression of novel 60-kDa and 110-kDa EGFR isoforms in human placenta. Annals of the New York Academy of Sciences. 2003, 995 (1): 39–47. doi:10.1111/j.1749-6632.2003.tb03208.x. PMID 12814937.
- Adams TE, McKern NM, Ward CW. Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor. Growth Factors. 2005, 22 (2): 89–95. doi:10.1080/08977190410001700998. PMID 15253384.
- Ferguson KM. Active and inactive conformations of the epidermal growth factor receptor. Biochem. Soc. Trans.. 2005, 32 (Pt 5): 742–5. doi:10.1042/BST0320742. PMID 15494003.
- Chao C, Hellmich MR. Bi-directional signaling between gastrointestinal peptide hormone receptors and epidermal growth factor receptor. Growth Factors. 2005, 22 (4): 261–8. doi:10.1080/08977190412331286900. PMID 15621729.
- Carlsson J, Ren ZP, Wester K, et al.. Planning for intracavitary anti-EGFR radionuclide therapy of gliomas. Literature review and data on EGFR expression. J. Neurooncol.. 2006, 77 (1): 33–45. doi:10.1007/s11060-005-7410-z. PMID 16200342.
- Scartozzi M, Pierantoni C, Berardi R, et al.. Epidermal growth factor receptor: a promising therapeutic target for colorectal cancer. Anal. Quant. Cytol. Histol.. 2006, 28 (2): 61–8. PMID 16637508.
- Ahmed SM, Salgia R. Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer. Respirology. 2007, 11 (6): 687–92. doi:10.1111/j.1440-1843.2006.00887.x. PMID 17052295.
- Zhang X, Chang A. [http//www.ncbi.nlm.nih.gov/pmc/articles/PMC2598028/ Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer]. J. Med. Genet.. 2007, 44 (3): 166–72. doi:10.1136/jmg.2006.046102. PMID 17158592. PMC 2598028.
- Cohenuram M, Saif MW. Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, present and the future. JOP. 2007, 8 (1): 4–15. PMID 17228128.
- Mellinghoff IK, Cloughesy TF, Mischel PS. PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors. Clin. Cancer Res.. 2007, 13 (2 Pt 1): 378–81. doi:10.1158/1078-0432.CCR-06-1992. PMID 17255257.
- Nakamura JL. The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. Expert Opin. Ther. Targets. 2007, 11 (4): 463–72. doi:10.1517/14728222.11.4.463. PMID 17373877.
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